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The half life of lamotrigine is affected by other concomitant medications see Clinical Pharmacology 12. Among the 19 patients who subsequently enrolled in the HoFH extension study one discontinued because of increased transaminases that persisted mail order pamelor several dose reductions and one temporarily discontinued because of markedly elevated transaminases ALT 24x ULN AST 13x ULN that had several other causes including a drug drug interaction between JUXTAPID and the strong CYP3A4 inhibitor clarithromycin see Drug Interactions 7.
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In this randomized double blind placebo controlled trial 429patients were treated with conventional measures Step 1 AHA Diet and either LESCOL 40mg day or order pamelor by mail. They should be encouraged to be alert to the emergence of sadness worsening of depression withdrawal insomnia irritability hostility aggressiveness akathisia related restlessness anxiety agitation or panic attacks and to report such symptoms promptly to the patient s physician see Contraindications 4 Warnings and Precautions 5.
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